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Department of Pathology

Research

Department of Pathology was established in 1946. We currently specialize in　experimental pathology, with a focus on research and education.
Our research interest is to elucidate the mechanisms of diseases, particularly cancer development, progression, and metastasis. Our research is conducted using a wide variety of methods, including biochemical, molecular, and cell biological methods, as well as histopathological examination. Not only cultured cell lines but also mouse models of disease are employed. Especially in cancer research, we are currently interested in research using several kinds of transplantation models.

Members

Shogo Ehata Professor Molecular mechanism of metastasis in renal cancer
Molecular mechanism of metastasis in sarcoma
TGF-β family signaling in cancer development
Kosuke Oikawa Lecturer Functional analysis of myxoid liposarcoma-specific chimeric oncorotein, TLS-CHOP
Analysis of tumor-related functions of cohesin regulator, WAPL
Masako Nakanishi Lecturer Mechanism of cancer bone metastasis
Tumor microenvironment in tumor progression
Kazuki　Wakabayashi Assistant Professor 　
Rieko Tanibata Secretary 　
Mizuki　Nishikawa Graduate (Department of Human Pathology) 　
Kazuki　Shimomura Graduate (Second Department of Surgery) 　
Akiya Ibe Undergraduate 　
Kiyoto Morishita Undergraduate 　
Kurumi　Higashimoto Undergraduate 　
Yuka　Koyama Undergraduate 　

Publications (2021~)

  • Nakanishi M, Ibe A, Morishita K, Shinagawa K, Yamamoto Y, Takahashi H, Ikemori K, Muragaki Y, Ehata S.
    Acid-sensing receptor GPR4 plays a crucial role in lymphatic cancer metastasis.
    Cancer Sci. 2024 May;115(5):1551-1563.
  • Kato H, Hayami S, Ueno M, Suzaki N, Nakamura M, Yoshimura T, Miyamoto A, Shigekawa Y, Okada KI, Miyazawa M, Kitahata Y, Ehata S, Hamamoto R, Yamaue H, Kawai M.
    Histone methyltransferase SUV420H1/KMT5B contributes to poor prognosis in hepatocellular carcinoma.
    Cancer Sci. 2024 Feb;115(2):385-400.
  • Oikawa K, Kuroda M, Ehata S.
    Suppression of antitumor cytokine IL?24 by PRG4 and PAI?1 may promote myxoid liposarcoma cell survival.
    Biomed Rep. 2023 Jul 26;19(3):60.
  • Takahashi K, Abe K, Kubota SI, Morishita Y, Yoshimatsu Y, Hirakawa S, Kubota Y, Watabe T, Ehata S, Ueda HR, Shimamura T, Miyazono K.
    A new analysis modality for vascular structures combining tissue-clearing technology and topological data analysis.
    Nat Commun. 2022 Sep 12;13(1):5239.
  • Sato F, Kohsaka A, Tanimoto T, Bhawal UK, Muragaki Y.
    Histological analysis of a Becker muscular dystrophy case, diurnal expression of dystrophin in control mice and decreased expression of dystrophin in Bmal1 knockout mice.
    Histol Histopathol. 2022 Jul 25:18499.
  • Ehata S, Miyazono K.
    Bone Morphogenetic Protein Signaling in Cancer; Some Topics in the Recent 10 Years.
    Front Cell Dev Biol. 2022 May 25;10:883523.
  • Nishida J, Miyakuni K, Miyazono K, Ehata S.
    An in vivo orthotopic serial passaging model for a metastatic renal cancer study.
    STAR Protoc. 2022 Apr 18;3(2):101306.
  • Sato F, Bhawal UK, Osaki S, Sugiyama N, Oikawa K, Muragaki Y.
    Differential immunohistochemical expression of DEC1, CK?1ε, and CD44 in oral atypical squamous epithelium and carcinoma in situ.
    Mol Med Rep. 2022 May;25(5):159.
  • Kumagai K, Takanashi M, Ohno SI, Harada Y, Fujita K, Oikawa K, Sudo K, Ikeda SI, Nishi H, Oikawa K, Kuroda M.
    WAPL induces cervical intraepithelial neoplasia modulated with estrogen signaling without HPV E6/E7.
    Oncogene. 2021 May;40(21):3695-3706.
  • Murakami D, Kono M, Nanushaj D, Kaneko F, Zangari T, Muragaki Y, Weiser JN, Hotomi M.
    Exposure to Cigarette Smoke Enhances Pneumococcal Transmission Among Littermates in an Infant Mouse Model.
    Front Cell Infect Microbiol. 2021 Mar 31;11:651495.
  • Nakanishi M, Korechika A, Yamakawa H, Kawabe N, Nakai K, Muragaki Y.
    Acidic microenvironment induction of interleukin-8 expression and matrix metalloproteinase-2/-9 activation via acid-sensing ion channel 1 promotes breast cancer cell progression.
    Oncol Rep. 2021 Mar;45(3):1284-1294.
  • Ono K, Hata K, Nakamura E, Ishihara S, Kobayashi S, Nakanishi M, Yoshida M, Takahata Y, Murakami T, Takenoshita S, Komori T, Nishimura R, Yoneda T.
    Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2.
    Commun Biol. 2021 Mar 11;4(1):326.
  • Enaka M, Nakanishi M, Muragaki Y.
    The Gain-of-Function Mutation p53R248W Suppresses Cell Proliferation and Invasion of Oral Squamous Cell Carcinoma through the Down-Regulation of Keratin 17.
    Am J Pathol. 2021 Mar;191(3):555-566.